Immunoperoxidase technique in experimental chronic chagasic myocarditis
نویسندگان
چکیده
منابع مشابه
Pathogenesis of Chronic Chagasic Myocarditis
Chronic chagasic cardiomyopathy (CCC) is the most serious manifestation of the chronic form of Chagas’ disease and constitutes the most common type of chronic myocarditis in the world [1-5]. Chagas’ disease, a chronic illness caused by the flagellate parasite Trypanosoma cruzi (T. cruzi), was first described in 1909 by the Brazilian physician Carlos Chagas [6]. The insect vectors of the disease...
متن کاملRapid Progressive Chagasic Myocarditis: A Multifactorial Condition
Hollowed and others described a case of a rapidly progressing Chagas cardiomyopathy. This report highlights the importance of close monitoring of patients with Chagas disease and of offering antitrypanosomal therapy when indicated. However, factors that may have contributed to the rapid progression of the cardiomyopathy were lacking in the report. It is known that comorbidities such as human im...
متن کاملGene expression changes associated with myocarditis and fibrosis in hearts of mice with chronic chagasic cardiomyopathy.
Chronic chagasic cardiomyopathy is a leading cause of heart failure in Latin American countries. About 30% of Trypanosoma cruzi-infected individuals develop this severe symptomatic form of the disease, characterized by intense inflammatory response accompanied by fibrosis in the heart. We performed an extensive microarray analysis of hearts from a mouse model of this disease and identified sign...
متن کاملMurine heart gene expression during acute Chagasic myocarditis
Chagas disease is transmitted by the parasite, Trypanosoma cruzi. Acute infection is characterized by acute myocarditis, although it is largely asymptomatic. Initial cardiac insult could be a determinant to the posterior development of chronic Chagasic cardiomyopathy, usually after 10 years in only approximately 30% of chronically infected patients. Herein, we characterized the acute gene expre...
متن کاملMyocardial parasite persistence in chronic chagasic patients.
The persistence of Trypanosoma cruzi tissue forms was detected in the myocardium of seropositive individuals clinically diagnosed as chronic chagasic patients following endomyocardial biopsies (EMBs) processed by immunohistochemical (peroxidase-anti-peroxidase [PAP] staining) and molecular (polymerase chain reaction [PCR]) techniques. An indirect immunofluorescent technique revealed antigenic d...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Revista do Instituto de Medicina Tropical de São Paulo
سال: 1987
ISSN: 0036-4665
DOI: 10.1590/s0036-46651987000200001